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Although SSRIs are intended for chronic use in the treatment of depression and are designed to have pharmacokinetic profiles that would allow them to provide constant systemic concentration with long-term administrationthey may need days to weeks to reach a maximum steady-state concentration in order to exhibit efficacyHiemke and Hartter 2000ThereforeSSRIs are commonly used in a daily dosing schedule for the treatment of PEMontague et al 2004In addition to the potentially desirable side-effect of delaying ejaculationthis dosing regimen for long-acting SSRIs is associated with a number of undesirable side-effectssuch as decreased libido and EDMontague et al 2004With the success of daily SSRI use in delaying ejaculationit has been suggested that on-demand treatment with SSRIs possessing a short half-life and short T max would be equally effectivemore convenientand exhibit fewer serotonergic side-effects than observed with daily treatmentWaldinger 2005Thereforean ideal compound for the treatment of PE should exhibit pharmacokinetic profiles having rapid absorptionadequate availability to establish therapeutic exposure at the target siteand rapid elimination to reduce total drug exposure and minimize the incidence of side-effectsModi et al 2006

Dapoxetine is a safe and effective treatment for premature ejaculationPEbut it has a high discontinuation rateaccording to new research.

PE may be treated with sex therapymedicationsor a combination of these approachesDapoxetinea selective serotonin reuptake inhibitorSSRIis the only oral medication developed to treat PEIt is approved in 60 countries.

Premature ejaculationPEis the most common male sexual disorderestimated to affect up to 30of menOver the past one or two decadesclinical investigators have participated in an increasing number of studies that are helping in our understanding of PEwhich will undoubtedly facilitate future treatmentsApart from a number of behavioral approachesthe treatment of PE consists of primarily off-label use of oral selective serotonin reuptake inhibitorsSSRIsvia either on-demand or daily deliveryHowevervarious undesirable side-effects of these medications have led researchers to search for and develop new therapeutic approaches for PEDapoxetine is a short-acting SSRI developed specifically for the treatment of PEEarly trials with dapoxetine have documented successful outcomes without serious shortor long-term side-effectsThis review addresses the definitionclassificationdiagnosisphysiologyand neurobiopathology of PEand evaluates therapeutic strategies with novel treatments for PE.

To learn more about this studyyou or your doctor may contact the study research staff using the contact information provided by the sponsor.

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Tuncho Granados se graduó de Contador Público y Auditor, en la Universidad Rafael Landívar. Socio fundador del Consejo de Estudios Tributarios. Asesor en materia tributaria y editor de libros sobre impuestos.